3D Printing of Drug Nanocrystals for Film Formulations

The aim of the study was to prepare indomethacin nanocrystal-loaded, 3D-printed, fast-dissolving oral polymeric film formulations. Nanocrystals were produced by wet pearl milling technique, and 3D printing performed semi-solid extrusion method. Hydroxypropyl methyl cellulose (HPMC) film-forming polymer, glycerol plasticizer. In-depth physicochemical characterization made, including solid-state determination, particle size deviation analysis, appearance evaluation, determination weight variation, thickness, folding endurance, drug content uniformity, disintegration time, release testing. In nanocrystal studies, three different stabilizers tested. Poloxamer F68 smallest most homogeneous particles, with values 230 nm PI below 0.20, selected as a stabilizer for drug-loaded studies. polymer concentration first optimized drug-free best mechanical properties achieved films HPMC concentrations 2.85% (w/w) 3.5% (w/w), these two levels further Besides, in With optimum concentration, flexible homogeneous, disintegrated 1 2.5 min, released 2–3 min. Drug nanocrystals remained nano range films, sizes being all formulations from 300 500 nm. When 3D-printed compared traditional film-casted behavior pharmaceutical performance very similar. As conclusion, is promising option production immediate-release improved- solubility